Apply morning and evening to face and neck after cleaning before application of other treatments. If used as part of a NIOD regimen, apply after LVCE and/or SS, but before CAIS. Can be used on body areas if desired to improve water density and/or target oxidative stressors. If irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin. Patch testing prior to use is advised. Refer to our in-depth guide to patch testing. Keep out of reach of children.