If used as part of a NIOD regimen, apply to the neck and lower face areas in the morning and evening in this order after cleaning: CAIS, MMHC, NEC. If used as part of another skincare regimen, apply after serums but before any heavier creams. If NIOD HV is used, it should be applied after NEC. Apply to the neck and lower face areas in the AM and PM. If irritation occurs, cease use and consult a physician. Use only as directed on unbroken skin. Patch testing prior to use is advised. Keep out of reach of children.